A phase II trial was performed to investigate the efficacy and tolerance of combined gemcitabine and liposomal doxorubicin±recombinant human granulocyte colony-stimulating factor (G-CSF) in patients with chemotherapeutically pretreated metastatic breast cancer. http://www.nikefreernaustralia.nu Thirty-four patients were entered in this trial. Chemotherapy consisted of gemcitabine and liposomal doxorubicin±G-CSF. nikefreernaustralia Twenty seven patients received this regimen as 2nd line therapy, five patients as 3rd line and two patients as 4th line therapy after having failed taxane- and/or anthracycline-based chemotherapy or other drug combinations. After a median of six courses, an overall response rate of 26% (9 PR in 34 enrolled patients) was observed; 14 patients had disease stabilization (41%), and eight (24%) progressed. Three… patients were not evaluable for response due to anaphylaxis after the first course and protracted thrombocytopenia. The median TTP was 7.5 months, and median overall survival was 15 months.nike free rn 2018 australia Myelosuppression was the most frequently observed toxicity.https://en.wikipedia.org/wiki/Nike Non-haematological side effects were generally mild to moderate. Our data suggest that gemcitabine and liposomal doxorubicin±G-CSF is an effective and fairly well tolerated regimen for chemotherapeutically pretreated patients with advanced breast cancer.
Rikkunshi-to (TJ-43), a gastroprotective herbal medicine, has been used for the symptomatic relief of adult patients with dyspepsia. http://www.nikefreernaustralia.nu However, its mechanism has yet to be fully elucidated. The aim of this study is to evaluate the effect of TJ-43 on the gastric myoelectric activity in post-operative dyspeptic patients, whose symptoms persisted for over 1 year after gastrointestinal surgery. Electrogastrography (EGG) recordings were performed to calculate the biomechanical parameters on the dominant peak frequency (DPF).nike free rn womens australia Eight pediatric patients with dyspeptic symptoms after gastrointestinal surgery were examined and six age-matched children without any dyspeptic symptoms were used as controls, and they were compared with nine age-matched children without any dyspeptic symptoms after… gastrointestinal surgery as subcontrols. nikefreernaustralia All patients exhibited symptomatic relief after the administration of TJ-43, and the mean symptom score decreased significantly after the treatment of TJ-43 over a 1-month period.
Abstract:Fault attacks exploit hardware malfunctions to recover secrets from embedded electronic devices.http://www.nikefreernaustralia.nu In the late 90’s, Boneh, DeMillo and Lipton  introduced fault-based attacks on crt-rsa. These attacks factor the signer’s modulus when the message padding function is deterministic. However, the attack does not apply when the message is partially unknown, for example when it contains some randomness which is recovered only when verifying a correct signature. In this paper we successfully extends rsa fault attacks to a large class of partially known message configurations.nike free rn cmtr australia The new attacks rely on Coppersmith’s algorithm for finding small roots of multivariate polynomial equations. We illustrate the approach by successfully attacking several randomized… versions of the iso/iec 9796-2 encoding standard. nikefreernaustralia Practical experiments show that a 2048-bit modulus can be factored in less than a minute given one faulty signature containing 160 random bits and an unknown 160-bit message digest.